The 'Gossip Girl' star - who has her own lifestyle website Preserve - has revealed she is keen to attend a business course at the prestigious university.
When asked what she'd like to achieve, she said: "I have a dream to go to Harvard Business School and one of these days I will do that ... in my spare time!"
The 27-year-old actress - who has daughter James with Ryan Reynolds - insists, though, being a businesswoman in an "innate" mindset for her.
She added: "I love it but I think it's more innate for me; it's not something I went to college for. My mom is someone who faced a lot of obstacles but never took no for an answer and she showed me the only person who can limit you is yourself.
"Business is also about generosity. Entrepreneurs helping each other out. People starting their own companies who could be competitors are actually saying to me, 'This is a mistake I made and this is how you can do it better. Meet my technology officer who can teach you how to build your technology platform.' You realise there is room for everyone, as long as you work hard enough."
Meanwhile, Blake also opened up about the lack of opportunities available for women in the business world.
She told Stylist magazine: "There are a lot of women in business, but they don't get enough opportunities.
"If you look at the facts, women spend the most on e-commerce sites, yet less than 30% of the companies that venture capitalists fund are female-driven, even though female-run companies are the most successful. Women connect with other women. So why are we are not looking at the numbers?"
Update your news preferences and get the latest news delivered to your inbox.