A property in Munro St, Ayr has been significantly damaged by fire this afternoon.

Emergency services were first called to the property about 11.30am Saturday after a triple-0 call reporting the front room of the house was alight.

A Queensland Fire and Emergency Service spokeswoman said the house was well involved when fire crews arrived.

"They used multiple teams in breathing apparatus to extinguish the fire," the spokeswoman said.

"All persons were out of the house."

Fire crews were still dampening down hot spots and ventilating the property about 1pm.

The full extent of the damage to the house was unknown, but the spokeswoman said it was likely significant.

A Queensland Ambulance spokeswoman said paramedics were still on the scene and had treated two people, but had not yet transported anyone to hospital.

The nature of their injuries or conditions were unknown.

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